报告题目：Stereoselective Construction of Challenging C-C Bonds and the Development of Antimetastatic Agents
报告人：Professor P. Andrew Evans
Queen’s University, Canada
The seminar will describe the development and application of new stereoselective C-C bond forming reactions to the synthesis of bioactive agents. Specifically, it will outline a novel dynamic kinetic resolution of α,β-unsaturated aldehydes, the catalytic asymmetric alkylation of homoenolates and the development of a concise, efficient and scalable synthesis of antimetastatic agents.
Professor P. Andrew Evans is the Alfred R. Bader Chair of Organic Chemistry, a Tier 1 Canada Research Chair in Organic and Organometallic Chemistry in the Department of Chemistry at Queen’s University and a Changjiang Scholar at Central South University in China. He received a B.Sc. with honors in Applied Chemistry at Newcastle Polytechnic in 1987 and a Ph.D. at the University of Cambridge in 1991 under the supervision of Andrew B. Holmes, FRS. He then completed postdoctoral studies with Philip D. Magnus, FRS, at the University of Texas at Austin as a NATO Postdoctoral Fellow. In 1993 he initiated his independent career at the University of Delaware, where he was promoted to Professor before moving to Indiana University in 2001. In 2006, he moved to the University of Liverpool, where he was the Heath Harrison Chair of Organic Chemistry before moving to his current position in July 2012. Recent awards include the R. U. Lemieux Award, the Paul G. Gassman Distinguished Service Award, the Harry and Carol Mosher Award, an ACS Cope Scholar Award and the RSC Pedler Award. He has also served on the ACS Division of Organic Chemistry as a Member-at-Large, Councilor, National Organic Symposium Executive Officer and Division Chair. He is currently a co-chair of the highly acclaimed ACS-DOC Graduate Research Symposium. Additionally, he has served as an Associate Editor for Chem. Comm. and Synthesis. He is currently the Editor-in-Chief for Organic Reactions. He has published nearly 150 papers, articles, reviews, book chapters and monographs and delivered over 500 plenary and invited lectures.